Proven results for increasing adherence and improving health

Clinical evidence shows that using Smartinhaler™ technology in asthma substantially increases adherence to preventative and maintenance medications and reduces severe exacerbations in adults and children.

“Use of the Smartinhaler™ platform improved adherence to preventative medication by 180% and reduced use of reliever medication by 45% in a study of 220 children conducted over 4 years.”—


Below is a selection of peer-reviewed clinical publications arising from studies that have used the Smartinhaler™ platform:


Paediatric Clinical Studies

Burgess SW, Sly PD, Cooper PD, Devadason SG. Novel spacer device does not improve adherence in childhood asthma. Pediatr Pulmonol. 2007;42:736-739.


Burgess SW, Sly PD, Morawska A, Devadason SG. Assessing adherence and factors associated with adherence in young children with asthma. Respirology. 2008;13:559-563.


Schultz A, Sly PD, Zhang G, Venter A, le Souëf PN, Devadason SG. Incentive device improves spacer technique but not clinical outcome in preschool children with asthma. J Paediat Child Health. 2012;48(1):52-56.


Schultz A, Sly PD, Zhang G, Venter A, Davadason SG, le Souëf PN. Usefulness of parental response to questions about adherence to prescribed inhaled corticosteroids in young children. Arch Dis Child. 2012;97(12):1092-1096.


Klok T, Kaptein AA, Duiverman EJ, Brand PL. High inhaled corticosteroids adherence in childhood asthma: the role of medication beliefs. Eur Respir J. 2012;40(5):1149-1155.


Quak W, Klok T, Kaptein AA, Duiverman EJ, Brand PL. Preschool children with high adherence to inhaled corticosteroids for asthma do not show behavioural problems. Acta Paediat. 2012;101(11);1156-1160.


Klok T, Kaptein AA, Duiverman EJ, Brand PL. It’s the adherence, stupid (that determines asthma control in preschool children)! Eur Respir J. 2014;43(3):783-791.


Keemink YS, Klok T, Brand PLP. Long-term adherence to daily controller medication in children with asthma: the role of outpatient clinic visits. Pediatric Pulmonology December 2014. DOI 10.1002/ppul.23138


Chan AHY, Stewart AWS, Harrison J, Camargo C, Black PN, Mitchell EA. The effect of an inhaler with ringtones on asthma control and school attendance in children. Lancet Respir Med. 2015;3:210-219.



 Adult Clinical Studies

 Charles T, Quinn D, Weatherall M, Aldington S, Beasley R, Holt S. An audiovisual reminder function improves adherence with inhaled corticosteroid therapy in asthma. J Allergy Clin Immunol. 2007;119:811-816.


Perrin K, Williams M, Wijesinghe M, James K, Weatherall M, Beasley R. Randomized controlled trial of adherence with a single or combination inhaled corticosteroid/long-acting β-agonist inhaler therapy in asthma. J Allergy Clin Immunol. 2010;126:505-510.


Foster JM, Smith L, Bosnic-Anticevich SZ, Usherwood T, Sawyer SM, Rand CS, Reddel HK. Identifying patient-specific beliefs and behaviours for conversations about adherence in asthma. Int Med J. 2012;42:e136–e144.


Powell H, Murphy VE, Taylor DR, Hensley MJ, McCaffrey K, Giles W, et al. Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trial. Lancet. 2011;378:983-990.


Turton JA, Glasgow NJ, Brannan JD. Feasibility and acceptability of using bronchial hyperresponsiveness to manage asthma in primary care: a pilot study. Prim Care Respir J. 2012;21(1):28-34.


Patel M, Pilcher J, Travers J, Perrin K, Shaw D, Black P, et al. Use of a metered-dose inhaler electronic monitoring in real-world asthma randomized controlled trial. J Allergy Clin Immunol Pract. 2013;1(1):83-91.


Patel M, Pilcher J, Pritchard A, Perrin K, Travers J, Shaw D, et al. Efficacy and safety of maintenance and reliever combination budesonide-formoterol inhaler in patients with asthma at risk of severe exacerbations: a randomized controlled trial. Lancet Respir Med. 2013;1:32-42.


Patel M, Pilcher J, Reddel HK, Pritchard A, Corin A, Helm C, et al. Metrics of salbutamol use as predictors of future adverse outcomes in asthma. Clinical & Experimental Allergy. 2013;43:1144-1151.


Patel M, Pilcher J, Munro C, Hosking A, Pritchard A, Shaw D, et al. Short-acting β-agonist use as a marker of current asthma control. J Allergy Clin Immunol Pract. 2013;1:370-377.


Patel M, Perrin K, Pritchard A, Williams M, Wijesinghe M, Weatherall M, et al. Accuracy of patient self-report as a measure of inhaled asthma medication use. Respirology. 2013;18:546-552.


Foster JM, Smith L, Usherwood T, Sawyer SM, Reddel HK. Inhaler reminders improve adherence with controller treatment in primary care patients with asthma. J Allergy Clin Immunol. 2014;134(6):1260-1268.e3.



Smartinhaler™ Review Articles

Weinstein AG. The potential of asthma adherence management to enhance asthma guidelines. Ann Allergy Asthma Immunol. 2011;106:283-291.


Ingerski LM, Hente EA, Modi AC, Hommel KA. Electronic measurement of medication adherence in pediatric chronic illness: A review of measures. J Pediatr. 2011;159(4):528-534.


Boulet LP, Vervloet D, Magar Y, Foster JM. Adherence: The Goal to Control Asthma. Clin Chest Med. 2012;33:405-417.


Pritchard JN, Nikander K. Impact of intervention and feedback on adherence to treatment. Respiratory Drug Delivery 2012;271-282.


Chan AH, Reddel HK, Apter A, Eakin M, Riekert K, Foster JM. Adherence monitoring and e-health: How clinicians and researchers can use technology to promote inhaler adherence for asthma. J Allergy Clin Immunol Pract. 2013;1(5):446-454.


Morton RW, Everard ML, Elphick HE. Adherence in childhood asthma: the elephant in the room. Arch Dis Child. 2014. Downloaded from 02 June 2014 as 10.1136/archdischild-2014-306243.


Howard S, Lang A, Patel M, Sharples S, Shaw D. Electronic monitoring of adherence to inhaled medication in asthma. Current Respiratory Medicine Reviews. 2014;10:50-63.


Chan AH, Harrison J, Black PN, Mitchell EA, Foster JM. Using electronic monitoring devices to measure inhaler adherence: A practical guide for clinicians. J Allergy Clin Immunol Pract 2015;3:335-49.


  1. Chan AHY, Stewart AWS, Harrison J, Camargo C, Black PN, Mitchell EA. The effect of an inhaler with ringtones on asthma control and school attendance in children. Lancet Respir Med. 2015;3:210-219